2007;56(6):280-283. There is, for example, an algae extract trade-named Lanablue that comes from blue-green algae (green algae is rare, less than 1% of the total macroalgae in the world) and is claimed to have retinoid like effects (i.e. Sheng, J. P., Chen, H. R., and Shen, L. [Determination of six mineral elements in roots, stems, leaves, flowers and seeds of Scutellaria baicalensis by FAAS]. Taking Baikal skullcap might decrease how well the body gets rid of lithium. View abstract. Lee, C. Y., Wang, J. Y., Chen, T. C., Jiang, J. K., Peng, C. H., Kuo, C. D., Chang, W. C., Chiu, J. H., and Wu, C. W. Effects of S/B remedy containing Scutellaria baicalensis and Bupleurum scorzonerifolfium on hepatic interleukin-6 related signal transducer and activator of transcription 3 activation in mice through cell-cell interaction. View abstract. Alcohol: Alcohol interacts with Baicalin and can cause some serious Skullcap side effects like drowsiness, dizziness, and sleepiness. Interdiscip.Sci 2010;2(2):151-156. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version. 2010;17(1):47-54. Hu, J. Baikal skullcap might cause sleepiness and drowsiness. Journal of Chinese medicinal materials 2002;25(6):451-453. Extracts were added in the amount of 2.0 g/100 g of meat batter. Altavilla D, Squadrito F, Bitto A, et al. Woo, K. J., Lim, J. H., Suh, S. I., Kwon, Y. K., Shin, S. W., Kim, S. C., Choi, Y. H., Park, J. W., and Kwon, T. K. Differential inhibitory effects of baicalein and baicalin on LPS-induced cyclooxygenase-2 expression through inhibition of C/EBPbeta DNA-binding activity. Ren S, Cao D., Yang J, and et al. Bull Exp Biol Med 2004;137(5):471-474. View abstract. Udintsev, S. N., Razina, T. G., and Iaremenko, K. V. [The antitumor effect of Baikal skullcap]. A proprietary aqueous S. barbata extract appears to target tumor mitochondria to induce ROS generation and DNA damage followed by PARP hyperactivation, cellular ATP and NAD depletion, and glycolysis inhibition(33). Baikal skullcap is POSSIBLY SAFE for most adults when taken by mouth. Neo-clerodane diterpenoids also have demonstrated anticancer(24) and antiviral(25) activities. Ciesielska, E., Wolszczak, M., Gulanowski, B., Szulawska, A., Kochman, A., and Metodiewa, D. In vitro antileukemic, antioxidant and prooxidant activities of Antoksyd S (C/E/XXI): a comparison with baicalin and baicalein. View abstract. View abstract. WebBaicalin extracts have strong anti-inflammatory effects. Chinese medicinal herbs modulate mutagenesis, DNA binding and metabolism of benzo[a]pyrene 7,8-dihydrodiol and benzo[a]pyrene 7,8-dihydrodiol-9,10-epoxide. View abstract. 2019;49(4):544-546. Tyrosinase is a key enzyme involved in the synthesis of melanin, the pigment that gives skin color. Limit doses of American skullcap to no more than the package recommendation. J Med Food 2007;10:442-51. Bull Exp Biol Med 2002;134(1):47-49. Nontoxic; LD 50 is tested, none. Chang, Y. L., Shen, J. J., Wung, B. S., Cheng, J. J., and Wang, D. L. Chinese herbal remedy wogonin inhibits monocyte chemotactic protein-1 gene expression in human endothelial cells. Bochorakova, H., Paulova, H., Slanina, J., Musil, P., and Taborska, E. Main flavonoids in the root of Scutellaria baicalensis cultivated in Europe and their comparative antiradical properties. Vitamin D Deficiency: How Much Vitamin D Is Enough? Wang, H. W., Lin, C. P., Chiu, J. H., Chow, K. C., Kuo, K. T., Lin, C. S., and Wang, L. S. Reversal of inflammation-associated dihydrodiol dehydrogenases (AKR1C1 and AKR1C2) overexpression and drug resistance in nonsmall cell lung cancer cells by wogonin and chrysin. View abstract. Regulska-Ilow, B., Biernat, J., Grajeta, H., Ilow, R., and Drzewicka, M. Influence of bioflavonoids from the radix extract of Scutellaria baicalensis on the level of serum lipids, and the development of laboratory rats fed with fresh and oxidized fats. Whether co-administration of garlic has negative influence on Scutellaria baicalensis Georgi in treating models rats with pelvic inflammation? Homma, M., Oka, K., Taniguchi, C., Niitsuma, T., and Hayashi, T. Systematic analysis of post-administrative saiboku-to urine by liquid chromatography to determine pharmacokinetics of traditional Chinese medicine. View abstract. Burnett BP, Jia Q, Zhao Y, Levy RM. J Dent Res 1982;61(9):1103-1106. Phytother.Res 2003;17(6):640-644. Effects of Mg-ATP on the flavonoid production in the Scutellaria baicalensis Georgii suspension cultures. View abstract. View abstract. With cancer, where you get treated first matters. Zhou J, Qu F, Yu Y, et al. Induction of apoptosis in prostate cancer cell lines by a flavonoid, baicalin. Diabetes medicines: These Badaoui A. Allergic contact dermatitis to resveratrol and Scutellaria baicalensis root extract in a cosmetic product. Herbal hepatoxicity from Chinese skullcap: A case report. Macrophages are specifically involved in the initiation, maintenance, and resolution of inflammation. View abstract. 1997;52(11-12):817-823. Luna-Bastante L, Gatica-Ortega ME, Pastor-Nieto MA, et al. This will help them manage your care and keep you safe. J Pharm Pharmacol 1997;49(8):816-822. J Med Food 2009;12:1143-8. Food Chem Toxicol. Biol Pharm Bull 2003;26(1):79-83. View abstract. Smol'ianinov ES, Gol'dberg VE, Matiash MG, et al. View abstract. A number of constituents including flavonoids are thought to be responsible for these activities. Scientific and clinical relevance to the fact is not determined, but it is better to stay on the safer side. Baikal skullcap might have some of the same effects as estrogen. Kim, B. R., Kim, D. H., Park, R., Kwon, K. B., Ryu, D. G., Kim, Y. C., Kim, N. Y., Jeong, S., Kang, B. K., and Kim, K. S. Effect of an extract of the root of Scutellaria baicalensis and its flavonoids on aflatoxin B1 oxidizing cytochrome P450 enzymes. Arch Dis Child 1993;68:468-71. Bochorakova, H., Paulova, H., Slanina, J., Musil, P., and Taborska, E. Main flavonoids in the root of Scutellaria baicalensis cultivated in Europe and their comparative antiradical properties. Major issues are not reported regarding the result of this Chinese herb, but it is mandatory to take some of the mandatory precautions. Clin Transl Sci 2021;14(5):2017-2024. Call a physician if symptoms develop or persist. Huang KC. A Scutellaria Baicalensis Root Extract trade name mixture (30% ethanol extract) is reported to contain flavonoid compounds. Jiang, R. H., Su, W. C., Liu, H. F., Huang, H. S., and Chao, J. I. View abstract. Baikal skullcap might decrease how quickly the liver breaks down some medications. Preliminary study of traditional Chinese medicine treatment of minimal brain dysfunction: analysis of 100 cases. Fu, J., Cao, H., Wang, N., Zheng, X., Lu, Y., Liu, X., Yang, D., Li, B., Zheng, J., and Zhou, H. An anti-sepsis monomer, 2',5,6',7-tetrahydroxyflavanonol (THF), identified from Scutellaria baicalensis Georgi neutralizes lipopolysaccharide in vitro and in vivo. As one of the most popular and versatile herbs used in China, Scutellaria baicalensis (S. baicalensis) has attracted many researchers attention in recent years. Monitor your blood sugar closely. It is used with other herbs in traditional Chinese medicine to treat bacterial infections, hepatitis, and tumors. (detailed description of each of the ratings). J Altern Complement Med 2002;8(5):567-572. The antiinflammatory and analgesic effects of baicalin in carrageenan-evoked thermal hyperalgesia. Baikal skullcap might have an effect like a water pill or "diuretic." 2009;86(2):79-84. Eye contact Rinse with water. Ceska.Slov.Farm. Scheck, A. C., Perry, K., Hank, N. C., and Clark, W. D. Anticancer activity of extracts derived from the mature roots of Scutellaria baicalensis on human malignant brain tumor cells. In lung tumor models, S. barbata inhibits hypoxia-inducible factor-1 alpha and VEGF expression(18). View abstract. 2020 Apr;82(4):253-254. Afr J Tradit Complement Altern Med. Chinese skullcap can decrease the blood level of several drugs used to lower cholesterol levels. Leung, H. W., Yang, W. H., Lai, M. Y., Lin, C. J., and Lee, H. Z. Inhibition of 12-lipoxygenase during baicalein-induced human lung nonsmall carcinoma H460 cell apoptosis. Wang, Z. View abstract. Details. A traditional View abstract. Razina, T. G., Udintsev, S. N., Tiutrin, I. I., Borovskaia, T. G., and Iaremenko, K. V. [The role of thrombocyte aggregation function in the mechanism of the antimetastatic action of an extract of Baikal skullcap]. WebAbstract This study was carried out to investigate the antifibrotic effects of methanol extracts from the traditional Chinese medicinal herb, the root of Scutellaria baicalensis Georgi, on liver fibrosis induced by bile duct ligation and scission Pharmacol Biochem Behav 2009;92(4):642-648. View abstract. Dry extract of Scutellaria baicalensis as a hemostimulant in antineoplastic chemotherapy in patients with lung cancer. View abstract. J Ethnopharmacol. J Ethnopharmacol. Taking Baikal skullcap along with diabetes medications might cause your blood sugar to go too low. Z., Jing, X. L., Guo, X. H., and Zhu, Y. Y. Zhang S, Cheng Z, Huang B, and Li J. Fitoterapia 2009;80(7):448-452. View abstract. Baikal skullcap is also sometimes applied to the skin for psoriasis. Zhao, Y., Li, H., Gao, Z., Gong, Y., and Xu, H. Effects of flavonoids extracted from Scutellaria baicalensis Georgi on hemin-nitrite-H2O2 induced liver injury. 11-12-2009;126(2):320-331. Shieh, D. E., Cheng, H. Y., Yen, M. H., Chiang, L. C., and Lin, C. C. Baicalin-induced apoptosis is mediated by Bcl-2-dependent, but not p53-dependent, pathway in human leukemia cell lines. View abstract. Indian J Med Res 2008;127(6):610-615. Zhou, J., Qu, F., Zhang, H. J., Zhuge, X. H., and Cheng, L. Z. Diabetes medications are also used to lower blood sugar. A Medicinal Plant Extract of Scutellaria Baicalensis and Acacia Catechu Reduced LPS-Stimulated Gene Expression in Immune Cells: A Comprehensive Genomic Study Using QPCR, ELISA, and Microarray. J Med Food 2009;12:1143-8. Kimura, Y., Matsushita, N., and Okuda, H. Effects of baicalein isolated from Scutellaria baicalensis on interleukin 1 beta- and tumor necrosis factor alpha-induced adhesion molecule expression in cultured human umbilical vein endothelial cells. View abstract. First-aid measures Inhalation Move to fresh air. Scutellaria baicalensisis used in traditional medicine to treat many medical conditions, but studies in humans are limited.S. Analysis of essential oils from different organs of Scutellaria baicalensis. Z Naturforsch.C. Some sedative medications include clonazepam (Klonopin), lorazepam (Ativan), phenobarbital (Donnatal), zolpidem (Ambien), and others. Sasaki, K., Taura, F., Shoyama, Y., and Morimoto, S. Molecular characterization of a novel beta-glucuronidase from Scutellaria baicalensis georgi. 73.^ Hwang YK, Jinhua M, Choi BR, Cui CA, Jeon WK, Kim H, Kim HY, Han SH, Han JS Effects of Scutellaria baicalensis on chronic cerebral hypoperfusion-induced memory impairments and chronic lipopolysaccharide infusion-induced memory impairments J Ethnopharmacol. The flavonoid baicalin exhibits anti-inflammatory activity by binding to chemokines. Small studies also suggest it is safe and may benefit patients with advanced breast cancer(13)(14). B., Ro, J. Y., and Woo, S. S. Antiallergic herbal composition from Scutellaria baicalensis and Phyllostachys edulis. Intern Med 2001;40:764-8. Chou TC, Chang LP, Li CY, et al. B., and Chun, M. Anti-inflammatory effects of Scutellaria baicalensis extract via suppression of immune modulators and MAP kinase signaling molecules. Takeshita K, Saisho Y, Kitamura K, et al. At this time there is not enough scientific information to determine an appropriate range of doses for Baikal skullcap. This herb has also given great results when used as a liver-protectant; therefore, there is no surety whether it is bad or good for humans. View abstract. J Agric Food Chem 12-3-2003;51(25):7276-7279. Guang.Pu.Xue.Yu Guang.Pu.Fen.Xi. 4-12-2011;134(3):884-891. Li BQ, Fu T, Gong WH, et al. View abstract. People with diabetes should not take Chinese skullcap without consulting a doctor as it may lower blood sugar, increasing the risk of hypoglycemia. Zhongguo Zhong.Yao Za Zhi 2008;33(9):1064-1066. A preliminary study of S. baicalensis along with metformin appeared to improved glucose tolerance, inflammation, and gut microbiota in patients with type 2 diabetes(23). Jeong, K., Shin, Y. C., Park, S., Park, J. S., Kim, N., Um, J. Y., Go, H., Sun, S., Lee, S., Park, W., Choi, Y., Song, Y., Kim, G., Jeon, C., Park, J., Lee, K., Bang, O., and Ko, S. G. Ethanol extract of Scutellaria baicalensis Georgi prevents oxidative damage and neuroinflammation and memorial impairments in artificial senescense mice. Mu, X., He, G., Cheng, Y., Li, X., Xu, B., and Du, G. Baicalein exerts neuroprotective effects in 6-hydroxydopamine-induced experimental parkinsonism in vivo and in vitro. Altern.Ther.Health Med. A., Lee, K., Hwangbo, H., Park, E., Kim, M., and Ma, W. Detection of the potential adulterant Teucrium chamaedrys in Scutellaria baicalensis raw material and extract by high-performance thin-layer chromatography. Have some of the ratings ), the pigment that gives skin color of g/100! Range of doses for Baikal skullcap might have an effect like a water pill or ``.. 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